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Repairing the Brain by SCF+G-CSF Treatment at 6 Months Postexperimental Stroke

Overview of attention for article published in ASN Neuro, August 2016
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Title
Repairing the Brain by SCF+G-CSF Treatment at 6 Months Postexperimental Stroke
Published in
ASN Neuro, August 2016
DOI 10.1177/1759091416655010
Pubmed ID
Authors

Lili Cui, Dandan Wang, Sandra McGillis, Michele Kyle, Li-Ru Zhao

Abstract

Stroke, a leading cause of adult disability in the world, is a severe medical condition with limited treatment. Physical therapy, the only treatment available for stroke rehabilitation, appears to be effective within 6 months post-stroke. Here, we have mechanistically determined the efficacy of combined two hematopoietic growth factors, stem cell factor (SCF) and granulocyte-colony stimulating factor (G-CSF; SCF + G-CSF), in brain repair 6 months after cortical infarct induction in the transgenic mice carrying yellow fluorescent protein in Layer V pyramidal neurons (Thy1-YFP-H). Using a combination of live brain imaging, whole brain imaging, molecular manipulation, synaptic and vascular assessments, and motor function examination, we found that SCF + G-CSF promoted mushroom spine formation, enlarged postsynaptic membrane size, and increased postsynaptic density-95 accumulation and blood vessel density in the peri-infarct cavity cortex; and that SCF + G-CSF treatment improved motor functional recovery. The SCF + G-CSF-enhanced motor functional recovery was dependent on the synaptic and vascular regeneration in the peri-infarct cavity cortex. These data suggest that a stroke-damaged brain is repairable by SCF + G-CSF even 6 months after the lesion occurs. This study provides novel insights into the development of new restorative strategies for stroke recovery.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 22%
Student > Ph. D. Student 2 11%
Student > Doctoral Student 2 11%
Student > Master 2 11%
Librarian 1 6%
Other 1 6%
Unknown 6 33%
Readers by discipline Count As %
Medicine and Dentistry 3 17%
Neuroscience 3 17%
Biochemistry, Genetics and Molecular Biology 1 6%
Sports and Recreations 1 6%
Nursing and Health Professions 1 6%
Other 2 11%
Unknown 7 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 May 2018.
All research outputs
#15,568,718
of 25,992,468 outputs
Outputs from ASN Neuro
#1
of 1 outputs
Outputs of similar age
#214,734
of 378,525 outputs
Outputs of similar age from ASN Neuro
#1
of 1 outputs
Altmetric has tracked 25,992,468 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1 research outputs from this source. They receive a mean Attention Score of 2.0. This one scored the same or higher as 0 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 378,525 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them